Septerna (SEPN) Stock Forecast and Price Target (2026)
Last updated July 2026
Short answer
9 analysts covering Septerna (SEPN) carry an average price target of $45.44 as of August 2026, -4.9% against the $47.76 price at the time of the pull. The published targets run from $38.00 to $60.00, a spread of 48% of the average, so the disagreement is moderate. The rating split is 10 buy, 0 hold, 0 sell. A price target is what an analyst published on a date, not a prediction, and sell-side ratings skew positive across the whole market. Walnut is not an investment adviser.
SEPN analyst price targets
SEPN analyst data as of August 2026, sourced from Yahoo Finance and may be delayed. A price target is what an analyst published on a date, not a forecast Walnut endorses, and targets are typically set on a 12-month view. Verify current figures before deciding.
The average target of $45.44 sits roughly in line with the $47.76 price, -4.9%. The median is $43.00, and where the two differ the median is the steadier read, because one unusually high or low target cannot drag it.
What the SEPN target range actually tells you
The published targets span $38.00 to $60.00. That gap is 48% of the average target, which counts as moderate disagreement. That is a fairly typical spread: enough agreement that the average means something, enough disagreement that it should not be treated as precise.
The useful move is to read the high target as one bull scenario and the low target as one bear scenario, then ask which set of assumptions you find more plausible. Both cases are worked through on the SEPN is it a buy page.
Recent analyst actions on SEPN
| Firm | Action | Target | Prior | Date |
|---|---|---|---|---|
| Wells Fargo | Raised (Overweight) | $50.00 | $48.00 | August 12, 2026 |
| HC Wainwright & Co. | Raised (Buy) | $60.00 | $40.00 | August 12, 2026 |
| Guggenheim | Raised (Buy) | $51.00 | $45.00 | August 11, 2026 |
| Guggenheim | Lowered (Buy) | $45.00 | $52.00 | July 1, 2026 |
| HC Wainwright & Co. | Maintained (Buy) | $40.00 | $40.00 | July 1, 2026 |
| Truist Securities | Raised (Buy) | $43.00 | $35.00 | July 1, 2026 |
| Raymond James | Raised (Strong Buy) | $53.00 | $47.00 | June 8, 2026 |
| JP Morgan | Raised (Overweight) | $38.00 | $34.00 | March 24, 2026 |
| Truist Securities | Raised (Buy) | $35.00 | $34.00 | March 11, 2026 |
| Wells Fargo | Raised (Overweight) | $48.00 | $28.00 | March 3, 2026 |
The most recent published rating actions on SEPN within the last six months, from Yahoo Finance. Each row is dated because a target only means something alongside the date it was set. Walnut is not an investment adviser and does not endorse any of these views.
In the last six months there have been 8 raises and 1 cut among these actions. The direction of revisions is often more telling than the level, because it shows which way informed opinion is moving. Note the tension here: the average target sits below the current price, yet the recent individual actions have mostly been raises. That usually means the published average has not caught up with the most recent revisions, and it is a good reason not to lean on the average alone.
How analysts rate SEPN
Of the analysts with a published rating, 10 say buy, 0 say hold, and 0 say sell, so 100% carry a buy. That mix has been broadly steady over the last three months.
Read the distribution rather than the label. Sell ratings are rare across the entire market for structural reasons, so a stock with no sell ratings is unremarkable, while even a handful of them is worth understanding.
Why a SEPN price target is not a prediction
- It is a 12-month model output. An analyst picks assumptions for revenue, margin, and a multiple, and the target falls out of the arithmetic. Change one assumption and the target moves a lot.
- The distribution is skewed. Sell-side coverage carries far more buy ratings than sell ratings across the whole market, so the average is not a balanced vote.
- Targets follow price as often as they lead it. Revisions frequently arrive after a move, not before, which is why a rising target is weak evidence on its own.
- Nobody is scored on it. There is no cost to a target that never gets close, so treat accuracy as unverified unless you check the firm's record yourself.
What could move SEPN from here
In short: the drivers cited most often are The Novo Nordisk collaboration, SEP-631 into Phase 2b, SEP-479 and the second attempt at oral hypoparathyroidism. The risk cited most often against it is every clinical-stage biotech carries binary risk, and here it has already been demonstrated: SEP-786 was discontinued in February 2025 after two severe cases of elevated unconjugated bilirubin, and the stock fell 47% that day.
Both sides are worked through properly, with the high and low targets used as the bull and bear anchors, on the SEPN is it a buy page. This page deliberately stops at the numbers.
Investing in Septerna with AI
Connect the broker you already use and ask Walnut's AI how SEPN fits what you actually hold: whether you own it already through a fund, what it would do to your concentration, and how it has tracked the S&P 500. Read-only by default, and you approve anything before it reaches your broker.
FAQ
What is the price target for Septerna (SEPN)?
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The average analyst price target for SEPN is $45.44 as of August 2026, across 9 analysts. That is -4.9% against the $47.76 price at the time of the data pull, so the consensus sits roughly in line with where the stock trades. The median target, which is less distorted by one extreme view, is $43.00. Targets move constantly; verify the current figure before relying on it.
How high could SEPN go?
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The highest published target is $60.00, which is +25.6% against the $47.76 price. That is one analyst's most optimistic case, not a ceiling and not a forecast. The lowest is $38.00. The gap between them is the honest answer to this question: analysts who all follow Septerna closely disagree by 48% of the average target, so treat any single number as one scenario.
How many analysts cover SEPN?
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9 analysts publish estimates on SEPN as of August 2026. Of those with a published rating, 10 say buy, 0 hold, and 0 sell, so 100% carry a buy rating. More coverage usually means the consensus is better informed, though it also means the obvious points are already in the price.
Are analyst price targets for SEPN accurate?
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Treat them as informed opinion, not measurement. Two things are worth knowing. Sell-side ratings skew positive across the market, and SEPN is no exception at 100% buy ratings, so the distribution is not a balanced vote. And targets tend to follow the share price at least as often as they lead it, getting raised after a stock has already run. They are most useful as a read on what the informed consensus expects, and least useful as a prediction of where the price lands.
Has the SEPN price target been raised or cut recently?
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In the last six months there have been 8 raises and 1 cut among the published actions on SEPN. The most recent was Wells Fargo, which raised its target to $50.00 from $48.00 on August 12, 2026. The direction of revisions often tells you more than the level, because it shows which way the informed view is moving.
Will SEPN go up in 2026?
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Nobody knows, including the analysts publishing targets. What the numbers on this page tell you is where informed opinion currently sits and how much it disagrees with itself, which is genuinely useful and completely different from a prediction. The risk most often cited against Septerna: Every clinical-stage biotech carries binary risk, and here it has already been demonstrated: SEP-786 was discontinued in February 2025 after two severe cases of elevated unconjugated bilirubin, and the stock fell 47% that day. Walnut is not an investment adviser.
Walnut is informational, not investment advice, and does not publish price targets of its own. The analyst figures on this page come from a August 2026 data pull of published third-party research, are approximate, and change constantly. Verify current figures with your broker before acting on them.